miR-139-5p Regulates <i>PIEZO1</i> Expression to Modulate Radiation-induced Injury in Type II Alveolar Epithelial Cells: A Hypothesis

Radiation-induced pulmonary injury (RIPI) is a common adverse reaction when ionizing radiation acts on the lung. Type II alveolar epithelial cells participate in process of RIPI by regulating inflammation, epithelial-mesenchymal transition, cellular senescence, etc. The expression miR-139-5p inhibited radiation, which plays role modulating radiotherapy resistance breast cancer tissues. PIEZO1, mechano-sensitive ion channel, has been found to play an essential bleomycin-induced lung fibrosis. Moreover, there exist some mechanisms between fibrosis and RIPI. stretch changes during might also regulate PIEZO1 signaling. Furthermore, predicted be downstream target gene miR-139-5p, leads increased mRNA protein expression. We hypothesized that modulate radiation-induced type cells. Therefore, it great practical significance explore new ways prevent treat break through existing research bottlenecks for improving prevention treatment